Acute Myocardial Ischemia Interferes with Class III Action of MS-551.
نویسندگان
چکیده
منابع مشابه
Electrophysiological effects of MS-551, a new class III agent: comparison with dl-sotalol in dogs.
MS-551 is a newly synthesized, nonspecific K+ channel blocker. To elucidate its electrophysiological and potential proarrhythmic effects relative to those of dl-sotalol in vivo, serial changes in ECGs, endocardial and epicardial monophasic action potential durations, and left and right ventricular pressures were measured simultaneously in pentobarbital-anesthetized open-chest dogs. Complete hea...
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Nifekalant hydrocholoride, a novel class III antiarrhythmic agent, was used as the treatment in 4 patients with extensive anterior infarction and severe ventricular dysfunction. The malignant ventricular tachyarrhythmia was effectively suppressed at a relatively low dose, without compromising the hemodynamics, indicating that this potent K+ channel blocker has therapeutic potential for acute my...
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ژورنال
عنوان ژورنال: Japanese Journal of Electrocardiology
سال: 1997
ISSN: 1884-2437,0285-1660
DOI: 10.5105/jse.17.55